Using genomics in medicine

DNA-based screening and personal health: A points to consider statement for individuals and health-care providers from the American College of Medical Genetics and Genomics (ACMG)

Bean LJH, Scheuner MT, Murray MF, Biesecker LG, Green RC, Monaghan KG, Palomaki GE, Sharp RR, Trotter TL, Watson MS, Powell CM, ACMG Board of Directors

Genetics in Medicine April 2021

Precision Population Health initiative targets precision medicine delivery in primary care

Healthcare Innovation |

March 2021

Press

Joint project between Ariadne Labs and Genomes2People to create implementation pathways, tools and guides that work across various clinical contexts.

Ariadne Labs and Genomes2People launch new Precision Population Health initiative

PR Newswire |

March 2021

Press Release

The Precision Population Health (PPH) initiative, a collaboration between Genomes2People and Ariadne Labs, aims to solve the system challenges in adopting precision medicine in primary care, and bring about a promising, equitable approach to medicine for every patient, everywhere. Our vision is not to simply introduce new tools to primary care, but rather to transform … Continued

Development and validation of a comprehensive Genomics Knowledge Scale

Linderman MD, Suckiel SA, Thompson N, Weiss DJ, Roberts JS, Green RC

Public Health Genomics In Press

Discordant results between conventional newborn screening and genomic sequencing in the BabySeq Project

Wojcik MH, Zhang T, Ceyhan-Birsoy O, Genetti C, Lebo M, Yu TW, Parad RB, Holm IA, Rehm HL, Green RC, Beggs AH, Agrawal PB, BabySeq Project Team

Genetics in Medicine March 2021

ACMG lobbying state legislatures on genetic counselors’ scope of practice draws criticism

GenomeWeb |

March 2021

Press

In light of the ACMG’s lobbying of state legislatures concerning genetic counselors’ scope of practice, G2P’s director Dr. Green comments on the collaboration between physicians and genetic counselors, describing genetic counselors as “instigators and implementers” of genetic testing.

Precision population medicine in primary care: The Sanford Chip experience

Christensen KD, Bell M, Zawatsky CL, Galbraith LN, Green RC, Hutchinson AM, Jamal L, LeBlanc JL, Leonhard JR, Moore M, Mullineaux L, Petry N, Platt DM, Shaaban S, Schultz A, Tucker BD, Van Heukelom J, Wheeler E, Zoltick ES, Hajek C

Frontiers in Genetics March 2021

I’m 28 and I don’t know my family history – here’s how that affects my health

Well + Good |

February 2021

Press

28 year old Mercey Livingston shares about what it means to be adopted and not know important information related to family health history and genetic health. Livingston quotes G2P’s director, Dr. Robert Green, explaining the differences between direct to consumer testing and comprehensive testing options, as well as the value of working with a genetics … Continued

Universal newborn genetic screening for pediatric cancer predisposition syndromes: Model-based insights

Yeh JM, Stout NK, Chaudhry A, Christensen KD, Gooch M, McMahon PM, O'Brien G, Rehman N, Zawatsky CLB, Green RC, Lu CY, Rehm HL, Williams MS, Diller L, Wu AC

Genetics in Medicine March 2021

NOVA “Secrets in Our DNA” screening and panel discussion

Computer History Museum |

January 2021

Video

Following a screening of the NOVA documentary, “Secrets in our DNA,” the Computer History Museum hosted a panel with science and business experts about personal genetic testing. Click the link below to hear contributions by G2P director Dr. Green.

Secrets in our DNA

NOVA |

January 2021

Video

In this NOVA documentary, G2P director Dr. Green explains what DNA can reveal about our ancestry and health, and at what risk.

Polygenic risk scores in the clinic: New perspectives needed on familiar ethical issues

Lewis ACF, Green RC

Genome Medicine January 2021

Latest Med News Podcast: Episode 6 with Bethany Zettler

Latest Med News |

December 2020

Podcast

In this season finale of the Latest Med News Podcast, G2P’s Bethany Zettler shares about her work as lead genetic counselor of the Preventive Genomics Clinic and project manager of the MilSeq and BabySeq studies. Her work focuses on how genetic testing can help anyone understand their health risks and make proactive medical/lifestyle choices.

Franca Sozzani has inspired a scientific fund – And now a website

Vogue |

December 2020

Press

“Last year Sozzani’s son, the photographer and filmmaker Francesco Carrozzini, established the Franca Sozzani Fund for Preventive Genomics at Harvard University’s Brigham and Women’s Hospital with artist and investor D.A. Wallach and Genomes2People director Dr. Robert C. Green. Today marks the launch of thefrancafund.org. Its purpose is straightforward: to explain the fund’s mission, provide resources … Continued

Preventive genomics clinics: The future of precision medicine?

The Pathologist |

December 2020

Press

“Personal genetic testing is here to stay – so Bethany Zettler and Renée Pelletier recommend preventive genomics clinics as a way to offer the testing patients want without bypassing the guidance they need to fully understand their results.”

The future of genomics in Ireland – focus on genomics for health

Seoighe C, Bracken AP, Buckley P, Doran P, Green R, Healy S, Kavanagh D, Kenny E, Lawler M, Lowery M, Morris D, Morrissey D, O'Byrne JJ, Shields D, Smith O, Steward C, Sweeney B, Kolch W

HRB Open Research December 2020

DNA: The next vital sign

Brigham Health |

October 2020

Press

Brigham genomics clinic makes medicine personal—and preventive.

Race, ancestry, and representation: The role of genetic medicine

Medium |

September 2020

G2P Blog

Race is a social construct, but representation matters in genetic studies — and on that front, we have a long way to go. By Tala Berro, MS, CGC

Long-awaited progress in addressing genetic discrimination in the US

Lewis ACF, Green RC, Prince AER

Genetics in Medicine October 2020

Airmen and healthcare providers’ attitudes toward the use of genomic sequencing in the US Air Force: Findings from the MilSeq Project

Pereira S, Hsu RL, Islam R, Robinson JO, Ramapriyan R, Sirotich E, Maxwell MD, Majumder M, Blout C, Christensen KD, Mehlman M, Parasidis E, Gardner CL, Killian JM, De Castro M, Green RC, McGuire AL

Genetics in Medicine August 2020

Genomic sequencing to screen newborns raises more false alarms than routine blood tests

STAT |

August 2020

Press

In this study led by UCSF researchers, exome sequencing was found to produce more false positives and false negatives for inherited metabolic disorders than the standard blood testing conducted in newborns. G2P’s Dr. Robert Green, co-leader of the BabySeq Project, speaks to the possibility “that the most comprehensive screening for newborns will be some combination … Continued

FDA oversight of NSIGHT genomic research: The need for an integrated systems approach to regulation

Milko LV, Chen F, Chan K, Brower AM, Agrawal PB, Beggs AH, Berg JS, Brenner SE, Holm IA, Koenig BA, Parad RB, Powell CM, Kingsmore SF

npj Genomic Medicine December 2019

Biobanks could identify medically actionable findings relevant for COVID-19 clinical care

Stergachis AB, Weiss ST, and Green RC

Nature Medicine June 2020

Educating military primary health-care providers in genomic medicine: lessons learned from the MilSeq Project

Maxwell MD, Hsu R, Islam R, Robinson JO, Pereira S, Gardner CL, Green RC, De Castro M

Genetics in Medicine July 2020

Genetic counseling following direct-to-consumer genetic testing: Consumer perspectives

Marzulla T, Roberts JS, DeVries R, Koeller DR, Green RC, Uhlmann WR

Journal of Genetic Counseling February 2021

The Project Baseline Health Study: A step towards a broader mission to map human health

Gambhir S, Arges K, Assimes T, Bajaj V, Balu S, Bashir M, Beskow L, Blanco R, Califf R, Campbell P, Carin L, Christian V, Cousins S, Das M, Dockery M, Douglas P, Dunham A, Eckstrand J, Fleischmann D, Ford E, Fraulo E, French J, Ginsburg G, Green R... Shipes S, Sledge G, Spielman S, Spitler R, Schaack T, Swamy G, Willemink M, and Wong C

npj Digital Medicine June 2020

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

The COVID-19 Host Genetics Initiative

European Journal of Human Genetics May 2020

23andMe study to recruit sickest Covid-19 patients in bid to unravel role of genetics in disease

STAT |

May 2020

Press

Understanding the return of genomic sequencing results process: Content review of participant summary letters in the eMERGE research network

Lynch JA, Sharp RR, Aufox SA, Bland ST, Blout CL, Bowen DJ, Buchanan AH, Halverson C, Harr M, Hebbring SJ, Henrikson N, Hoell C, Holm IA, Jarvik G...Smith ME, Sturm A, Stuttgen K, Wiesner G, Williams MS, Wynn J, Williams JL

Journal of Personalized Medicine May 2020

Geneticist says DNA testing should be part of everyday healthcare

CNBC |

May 2020

Press, Video

Dr. Robert Green is the director of the Preventive Genomics Clinic at Brigham and Women’s Hospital in Boston. He believes that DNA testing combined with proper counseling and medical follow-up would be a critical element of a healthcare system that can prevent illness.

Coronavirus, the answer may be in your genes

Fox News |

May 2020

Press, Video

What do your genetics have to do with your chances of dying from Coronavirus?

Vanity Fair |

April 2020

Press

Our genes might make some of us more susceptible to COVID-19—but which genes? Geneticists are sharing their vast DNA databases to find out.

Heroes on the front line: Dr. Robert Green

Blue Cross Blue Shield Massachusetts |

April 2020

Press

“..There are researchers – every single scientist is thinking ‘how can I contribute?’”

Returning results in the genomic era: Initial experiences of the eMERGE network

Wiesner GL, Rahm AK, Appelbaum P, Aufox S, Bland S, Blout CL, Christensen KD, Chung WK, Clayton EQ, Green RC...Sharp RR, Smith ME, Van Driest SL, Williams JL, Williams MS, Wynn J, Leppig KA

Journal of Personalized Medicine April 2020

Clinical utility of genomic sequencing: a measurement toolkit

Hayeems RZ, Dimmock D, Bick D, Belmont JW, Green RC, Lanpher B, Jobanputra V, Mendoza R, Kulkarni S, Grove ME, Taylor SL, Ashley E

npj Genomic Medicine December 2020

Coronavirus: Genes may explain why some face greater danger than others

Fox News |

April 2020

Press

“While healthy young people as a group are less likely to have severe symptoms with COVID, they have to understand that some of them will become very ill and will even die from this infection,” Dr. Robert Green said. “No one should assume youth makes them invulnerable.”

Genome-wide association study of rate of cognitive decline in Alzheimer’s patients identifies novel genes and pathways

Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Bennett D, Chibnik L, Cruchaga C, Farrer L, Kraft P, Mayeux R, Munsie L, Newhouse S, Saykin A, Schellenberg G, the Alzheimer’s Disease Genetics Consortium, Crane PK, Green RC

Alzheimer's & Dementia June 2020

Multiple GYPB gene deletions associated with the U− phenotype in those of African Ancestry

Lane WJ, Gleadall NS, Aechlimann J, Vege S, Sanchis-Juan A, Stephens J, Sullivan JC, Mah HH, Aguad M, Smeland-Wagman R, Lebo MS, Kumar PKV, Kaufman RM, Green RC, Ouwehand WH, Westhoff CM

Transfusion May 2020