G2P Newsletter July 2021

July 2021
G2P News

Our G2P research team continues to be extraordinarily productive, publishing 21 scientific papers so far this year. This summer newsletter highlights a few of these papers, as well as G2P media features, blog posts, and policy recommendations.

Behavioral and psychological impact of genome sequencing: A pilot randomized trial of primary care and cardiology patients

Christensen KD, Schonman EF, Robinson JO, Roberts S, Diamond PM, Lee KB, Green RC, McGuire AL
npj Genomic Medicine In Press

Robert Green: Newborn Sequencing Is the Goal Here in the U.S.

Mendelspod |
July 2021
Podcast

“If you go to a scientific meeting, even with the greatest critics, and you ask, how many people in this audience believe that your entire genome will be part of your everyday medical care in fifty years, every person will raise their hand. So the only questions we’re debating are: how do we get there, … Continued

Return of individual research results: What do participants prefer and expect?

Sayeed S, Califf R, Green R, Wong C, Mahaffey K, Gambhir SS, Mega J, Patrick-Lake B, Frazier K, Pignone M, Hernandez A, Shah SH, Fan AC, Krug S, Shaack T, Shore S, Spielman S, Eckstrand J, Wong CA, for the Project Baseline Health Study Research Group 
PLOS ONE In Press

How will Aducanumab approval impact Alzheimer’s disease research?

Weiner MW, Aisen PS, Beckett LA, Green RC, Jagust William, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Mindt MR, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ and the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Journal of Prevention of Alzheimer's Disease July 2021  

Behavioral and psychological impact of genome sequencing: A pilot randomized trial of primary care and cardiology patients

Christensen KD, Schonman EF, Robinson JO, Roberts S, Diamond PM, Lee KB, Green RC, McGuire AL
npj Genomic Medicine In Press

Polygenic risk scores in the clinic: Translating risk into action

Lewis ACF, Green RC, Vassy JL
Human Genetics and Genomics In Press

Precision medicine: From breakthrough to follow-through

Medium |
May 2021
G2P Blog

Nic Encina, Director of Strategy of the Precision Population Health (PPH) Initiative at Ariadne Labs, describes the recent launch of PPH into the world of precision medicine. “We feel that Genomes2People’s real-world research in genomic return-of-results combined with Ariadne Labs’ practical approach to health system innovation and implementation are aptly suited for tackling implementation obstacles … Continued

The BabySeq Project: Phase II

May 2021

Background The original BabySeq Project was a first-of-its-kind randomized clinical trial designed to measure the utility of using genomic sequencing in routine newborn care.  The concept for this project is built off of the existing newborn screening program, an important public health initiative. All newborns born in the U.S. receive a heel stick blood test … Continued

Physician-directed genetic screening to evaluate personal risk for medically actionable​ disorders: A large multi-center cohort study

Haverfield EV, Esplin E, Aguilar S, Hatchell K, Ormond K, Hanson-Kahn A, Atwal P, Macklin-Mantia S, Hines S, Sak C, Tucker S, Bleyl S, Hulick P, Gordon O, Velsher L, Gu J, Weissman S, Kruisselbrink T, Abel C, Kettles M, Slavotinek A, Mendelsohn B, Green R, Aradhya S, Nussbaum R
BMC Medicine In Press

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, Wang C, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Bhattacharya R, Pirruccello JP, Pampana A, Loh PR, Kohli P, McCarroll SA, Kiryluk K, Neale B , Ionita-Laza I, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ, The Biobank Japan Project+, FinnGen Consortium+, Terao C, Zhao H, Ebert BL, COVID-19 Host Genetics Initiative+, Reilly MP, Ganna A, Machiela MJ, Genovese G, Natarajan P
Nature Medicine June 2021  

Precision Pioneers EP 4: Geneticist and Harvard professor, Robert Green on accelerating implementation of genomic medicine

The Genetics Podcast |
April 2021
Podcast

On this episode of The Genetics Podcast, Patrick is joined by Robert Green, a geneticist, Professor of Medicine at Harvard, and Director of the Preventive Genomics Clinic at Brigham Health, whose work centers around accelerating evidence based implementation of genomic medicine. Patrick and Robert discuss topics including testing for common complex disease risks in healthy … Continued

The psychosocial impact of newborn genomic sequencing on families in the BabySeq Project: A randomized clinical trial

Pereira S, Smith HS, Frankel LA, Christensen KD, Islam R, Robinson JO, Genetti CA, Zawatsky CLB, Zettler B, Parad RB, Waisbren SE, Beggs AH, Green RC, Holm IA, McGuire AL, BabySeq Project Team
JAMA Pediatrics In Press

Ariadne Labs and Genomes2People launch new Precision Population Health initiative

PR Newswire |
March 2021
Press Release

The Precision Population Health (PPH) initiative, a collaboration between Genomes2People and Ariadne Labs, aims to solve the system challenges in adopting precision medicine in primary care, and bring about a promising, equitable approach to medicine for every patient, everywhere. Our vision is not to simply introduce new tools to primary care, but rather to transform … Continued

I’m 28 and I don’t know my family history – here’s how that affects my health

Well + Good |
February 2021
Press

28 year old Mercey Livingston shares about what it means to be adopted and not know important information related to family health history and genetic health. Livingston quotes G2P’s director, Dr. Robert Green, explaining the differences between direct to consumer testing and comprehensive testing options, as well as the value of working with a genetics … Continued

A pharmacist’s journey into genomic medicine

Medium |
February 2021
G2P Blog

Former G2P trainee Cathelijne van der Wouden, PharmD, shares about her journey into genomic medicine as a pharmacist-in-training in this G2P blog post.

NOVA “Secrets in Our DNA” screening and panel discussion

Computer History Museum |
January 2021
Video

Following a screening of the NOVA documentary, “Secrets in our DNA,” the Computer History Museum hosted a panel with science and business experts about personal genetic testing. Click the link below to hear contributions by G2P director Dr. Green.

Secrets in our DNA

NOVA |
January 2021
Video

In this NOVA documentary, G2P director Dr. Green explains what DNA can reveal about our ancestry and health, and at what risk.

Latest Med News Podcast: Episode 6 with Bethany Zettler

Latest Med News |
December 2020
Podcast

In this season finale of the Latest Med News Podcast, G2P’s Bethany Zettler shares about her work as lead genetic counselor of the Preventive Genomics Clinic and project manager of the MilSeq and BabySeq studies. Her work focuses on how genetic testing can help anyone understand their health risks and make proactive medical/lifestyle choices.  

Franca Sozzani has inspired a scientific fund – And now a website

Vogue |
December 2020
Press

“Last year Sozzani’s son, the photographer and filmmaker Francesco Carrozzini, established the Franca Sozzani Fund for Preventive Genomics at Harvard University’s Brigham and Women’s Hospital with artist and investor D.A. Wallach and Genomes2People director Dr. Robert C. Green. Today marks the launch of thefrancafund.org. Its purpose is straightforward: to explain the fund’s mission, provide resources … Continued

Preventive genomics clinics: The future of precision medicine?

The Pathologist |
December 2020
Press

“Personal genetic testing is here to stay – so Bethany Zettler and Renée Pelletier recommend preventive genomics clinics as a way to offer the testing patients want without bypassing the guidance they need to fully understand their results.”

G2P Newsletter October 2020

October 2020
G2P News

Over the past few months, G2P faculty have attended numerous virtual conferences, been featured in the news and media, and contributed to studies involving the role of genetics in COVID-19. Many of our presentations are transitioning to a virtual format and shared on YouTube for all to view; make sure to check out our presentations … Continued

DNA: The next vital sign

Brigham Health |
October 2020
Press

Brigham genomics clinic makes medicine personal—and preventive.