Genomes2Veterans

Jason Vassy, MD, MPH, SM

As director of the Genomes2Veterans research program at the Veterans Affairs (VA) Boston Healthcare System, Jason Vassy, MD, MPH, SM, bridges the expertise of Genomes2People and the mission of bringing 21st century medical care to Veterans.

Current Genomes2Veterans research projects:

Integrating Pharmacogenetics in Clinical Care (I-PICC) Study
Funding: U.S. Department of Veterans Affairs Office of Research & Development IK2-CX001262
Project Manager: Charles Brunette, PhD

The I-PICC Study is a pragmatic randomized controlled trial of pharmacogenetic testing for statin myopathy risk in the eight primary care practices across VA Boston. Statin-naïve patients at higher risk for cardiovascular disease are randomly assigned at the point-of-care to have their primary care providers receive their SLCO1B1 genotype results at baseline or at the end of the study. Patients are followed in the electronic health record for 12 months for outcomes including cholesterol levels, statin-associated muscle symptoms, and concordance with cardiovascular disease and pharmacogenetic prescribing guidelines.

For more detailed information about the I-PICC Project, including study design and outcome measures, visit our clinical trial page:

I-PICC on ClinicalTrials.gov

 

The GenoVA Study: Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

Funding: NIH, National Human Genome Research Institute 1 R35 HG010706-01

Project Manager: Ashley Antwi, MPH, CHES

The GenoVA Study is a pragmatic randomized controlled trial in which primary care patients without a known diagnosis of any one of 6 target diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, and prostate cancer) will undergo clinical genotype testing to calculate their polygenic risk scores (PRS) for these 6 diseases. Patient-participants (including those with at least one PRS indicating high-risk (odds ratio, ORPRS, > 2.5) and those with no PRS indicating high-risk), will be randomized to have them and their primary care provider receive their PRS results at baseline or after a 24-month observation period, reported along with evidence-based screening and management recommendations. All patients will be observed for 24 months for the primary clinical outcome of time-to-diagnosis of any of the 6 target diseases.

GenoVA on ClinicalTrials.gov

Pharmacogenomics Testing for Veterans (PHASER) Program

Funding: Denny Sanford and Sanford Health

Project Coordinators: Ashley Antwi, MPH, CHES and Alicia Harrison

VA Boston is currently one of the first VA sites across the country participating in the PHASER program, a clinicalimplementation program and precision health initiative that provides preemptive pharmacogenomic (PGx) testing to current VA patients. The purpose of the program is to improve Veteran patients’ access to appropriate treatments and reduce adverse drug reactions.

To learn more about the PHASER program, visit our clinical trial page:

PHASER on ClinicalTrials.gov

Million Veteran Program – Return of Actionable Results (MVP-ROAR) Study

Funding: VA Office of Research and Development

Project Manager: Morgan Danowski, MS, CGC

The Million Veteran Program – Return of Actionable Results (MVP-ROAR) Study is a randomized controlled trial of immediate vs. delayed (after 6 months) return of medically actionable, clinically confirmed genetic testing results. The purpose of the study is to develop a process to return results to living MVP participants nationwide and to determine the impact of doing so on medical management and outcomes and Veteran quality of life.

For more detailed information about the MVP-ROAR Study, including study design and outcome measures, visit our clinical trial page: 

MVP-ROAR on ClinicalTrials.gov

Genomes2Veterans research team:

Ashley Antwi, MPH, CHES

Project Manager
Genomes2Veterans
(857) 364-6037

Charles Brunette, PhD

Project Manager
Genomes2Veterans
857-364-6324

Morgan Danowski, MS, CGC

Genetic Counselor
Genomes2Veterans
857-364-3182

Alicia Harrison

Research Coordinator
Genomes2Veterans

Natalie Jones

Project Coordinator
Genomes2Veterans

Jason Vassy, MD, MPH, SM

Assistant Professor, Medicine
Director, Genomes2Veterans
857-364-2561

 

For Genomes2Veterans scientific papers and media coverage, visit the link below.

G2V Publications

G2V News & Media