This fall, we are thrilled to welcome Dr. Amy Lemke to G2P! As Executive Director of the International Newborn Screening Consortium, Dr. Lemke is taking the BabySeq Project global. She will also join the Precision Population Health (PPH) Initiative, a collaboration between G2P and Ariadne Labs.
News & Media
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For the first time in history, we can treat the underlying cause of some genetic diseases — if we catch them early enough. What does this mean for public health?
This year, Erin Drake, MA, director of operations for G2P, and Tala Berro, MS, CGC, a genetic counselor and project manager, helped launch the G2P BIPOC internship program in recognition of the importance of diversity not only in clinical trials but also in research teams. Research trainees Soha Mohammed, Kopika Kuhathaas and Shardae Williams share … Continued
“We have a wild card here that is changing the risk-benefit equation for all babies in order to detect these rare cases.”
“Medical researchers in Boston are helping sign up one million volunteers for a first-of-its-kind study [The All of Us Research Program] examining the link between genes and our health. Researchers are actively recruiting volunteers of different races and ethnicities to ensure that the study reflects the diversity of the United States.”
Genomic testing for Baby Cora, a participant of The BabySeq Project, revealed a disorder that might otherwise have gone undetected through traditional newborn screening. “Cora’s case illustrates the promise of sequencing the entire genomes of newborns: uncovering a bounty of genetic information that could identify infants needing treatment and improve health later in life…Genomics England … Continued
“We have now shown that this information can be medically beneficial through early intervention and is not disruptive to the parent-infant relationship, and our ongoing analysis is measuring economic effects of genome sequencing. This type of research is critical to determine best practices for preventive genomic healthcare throughout the lifespan.” – Robert Green
“Researchers examined how conducting genome sequencing on newborns can impact family dynamics.”
“When parents were surveyed about measures like how well they bonded with their children, their levels of distress, and even the parents’ relationships with one another, there were no meaningful differences for parents whose children had their genomes sequenced compared to those whose children underwent standard newborn screening.”
“Researchers studying the psychosocial effect of newborn genomic sequencing on families in the BabySeq project have found that there was no persistent negative psychosocial harm in families who received such sequencing, nor among those who received a monogenic disease risk finding for their infants.”
“Robert Green, MD, MPH, of the Division of Genetics, received a research grant from the National Institutes of Health (NIH) to fund The BabySeq Project: Phase II, also known as BabySeq2, the continuation of a project to study genome sequencing in newborns.”
“Should people who volunteer for genomic studies be told about unrelated disease mutations that turn up in their sequence data?”
Our G2P research team continues to be extraordinarily productive, publishing 21 scientific papers so far this year. This summer newsletter highlights a few of these papers, as well as G2P media features, blog posts, and policy recommendations.
“If you go to a scientific meeting, even with the greatest critics, and you ask, how many people in this audience believe that your entire genome will be part of your everyday medical care in fifty years, every person will raise their hand. So the only questions we’re debating are: how do we get there, … Continued
In an unprecedented international effort, researchers and clinicians tackle the genomics of COVID-19 risk. In this blog post, G2P Director Robert Green writes about what we’ve learned so far concerning genetics and COVID-19 and how the G2P research program has contributed to these growing studies.
ZARA launches its first tribute collection, featuring iconic photographs by legendary image maker Peter Lindbergh. 100% of proceeds from this limited edition series curated by Fabien Baron will be donated to The Franca Sozzani Fund for Preventive Genomics, supporting the Global BabySeq Project in collaboration with Brigham and Women’s Hospital and Harvard Medical School.
“We might think that science and money have nothing to do with each other, but whether it’s video games, consumer DNA kits, or even the concrete we build with, the connections are everywhere. Listen to Dr. Mitu Khandaker, Dr. John Orr, and Dr. Jason Vassy explore what happens when research and commercial interests collide.”
Nic Encina, Director of Strategy of the Precision Population Health (PPH) Initiative at Ariadne Labs, describes the recent launch of PPH into the world of precision medicine. “We feel that Genomes2People’s real-world research in genomic return-of-results combined with Ariadne Labs’ practical approach to health system innovation and implementation are aptly suited for tackling implementation obstacles … Continued
Dr. Robert C. Green joins Patrick Short of “The Genetics Podcast” to discuss genetic testing in healthy adults and newborns, along with the barriers we need to overcome to realize the full potential of personalized medicine.
In this blog post, G2P trainee Sachi Badola speaks to the importance of genetic literacy and proposes a genetics elective to be offered to all high school students that comprehensively covers the implications, limitations, and challenges of genomic medicine and precision health.
Joint project between Ariadne Labs and Genomes2People to create implementation pathways, tools and guides that work across various clinical contexts.
The Precision Population Health (PPH) initiative, a collaboration between Genomes2People and Ariadne Labs, aims to solve the system challenges in adopting precision medicine in primary care, and bring about a promising, equitable approach to medicine for every patient, everywhere. Our vision is not to simply introduce new tools to primary care, but rather to transform … Continued
“In 2019, [G2V’s] Morgan Danowski graduated and joined Boston VA. There, she supports VA’s Million Veteran Program (MVP), now the world’s largest genomics research program. The program takes DNA from participating Veterans and information on their health, lifestyle and military experiences and exposures to better understand disease in Veteran populations. With over 830,000 Veterans enrolled, … Continued
Washington University researchers recently published a study in the New England Journal of Medicine reporting that it is often faster and more effective to sequence the genome of people with blood cancers than to order them traditional tests. Dr. Green says that the findings from this study are a start, but despite the tremendous enthusiasm … Continued
In light of the ACMG’s lobbying of state legislatures concerning genetic counselors’ scope of practice, G2P’s director Dr. Green comments on the collaboration between physicians and genetic counselors, describing genetic counselors as “instigators and implementers” of genetic testing.
Winter saw accomplishments by G2P team members through numerous projects, presentations and publications. Following the release of the NOVA documentary “Secrets in our DNA,” G2P Director Dr. Green spoke on a panel about genetics, ancestry, race and privacy issues. In December, G2P’s Carrie Blout and G2V’s Jason Vassy presented on pressing legal and policy issues … Continued
28 year old Mercey Livingston shares about what it means to be adopted and not know important information related to family health history and genetic health. Livingston quotes G2P’s director, Dr. Robert Green, explaining the differences between direct to consumer testing and comprehensive testing options, as well as the value of working with a genetics … Continued
Former G2P trainee Cathelijne van der Wouden, PharmD, shares about her journey into genomic medicine as a pharmacist-in-training in this G2P blog post.
In this article, Dr. Robert C. Green weighs in on 23andMe’s new interactive tool called the COVID-19 Severity Calculator. Right now the COVID-19 Severity Calculator only includes nongenetic risk factors for hospitalization from COVID-19. Dr. Green suspects that as more insights on genetic risk factors become available, 23andMe might begin incorporating genetic data into their … Continued
Following a screening of the NOVA documentary, “Secrets in our DNA,” the Computer History Museum hosted a panel with science and business experts about personal genetic testing. Click the link below to hear contributions by G2P director Dr. Green.
In this NOVA documentary, G2P director Dr. Green explains what DNA can reveal about our ancestry and health, and at what risk.
In this season finale of the Latest Med News Podcast, G2P’s Bethany Zettler shares about her work as lead genetic counselor of the Preventive Genomics Clinic and project manager of the MilSeq and BabySeq studies. Her work focuses on how genetic testing can help anyone understand their health risks and make proactive medical/lifestyle choices.
“Last year Sozzani’s son, the photographer and filmmaker Francesco Carrozzini, established the Franca Sozzani Fund for Preventive Genomics at Harvard University’s Brigham and Women’s Hospital with artist and investor D.A. Wallach and Genomes2People director Dr. Robert C. Green. Today marks the launch of thefrancafund.org. Its purpose is straightforward: to explain the fund’s mission, provide resources … Continued
“Personal genetic testing is here to stay – so Bethany Zettler and Renée Pelletier recommend preventive genomics clinics as a way to offer the testing patients want without bypassing the guidance they need to fully understand their results.”
Over the past few months, G2P faculty have attended numerous virtual conferences, been featured in the news and media, and contributed to studies involving the role of genetics in COVID-19. Many of our presentations are transitioning to a virtual format and shared on YouTube for all to view; make sure to check out our presentations … Continued
Brigham genomics clinic makes medicine personal—and preventive.
“Aging can be considered a disease—one that can be targeted, treated, and perhaps even reversed…The new Preventive Genomics Clinic at Brigham and Women’s Hospital in Boston is the first academic clinic in the country to offer comprehensive DNA sequencing and interpretation of nearly 6,000 disease-associated genes.”
Race is a social construct, but representation matters in genetic studies — and on that front, we have a long way to go. By Tala Berro, MS, CGC
In this study led by UCSF researchers, exome sequencing was found to produce more false positives and false negatives for inherited metabolic disorders than the standard blood testing conducted in newborns. G2P’s Dr. Robert Green, co-leader of the BabySeq Project, speaks to the possibility “that the most comprehensive screening for newborns will be some combination … Continued
In the first of a two-part series, AMA Chief Experience Officer Todd Unger discusses genetics at play in COVID-19 with experts Wendy Chung, MD, PhD, Robert Green, MD, MPH, and AMA’s Chief Health and Science Officer Mira Irons, MD.