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Mass General Brigham Broad Institute Harvard Medical School Ariadne Labs
G2P and collaborators gathered together in Boston for our annual holiday festivities

G2P co-hosted the inaugural International Conference on Newborn Sequencing this October at Boston's Museum of Science

Nation’s first academic clinic to offer comprehensive DNA sequencing and genetic risk assessment to healthy adults and children
Thrilled to announce the Precision Population Health (PPH) initiative, a collaboration between Ariadne Labs and Genomes2People
The second phase of BabySeq will expand and improve upon what we learned during the first iteration of the project
We're integrating genomics into medicine and society, and advocating for the future of medicine and health

We conduct research to accelerate the implementation of genomic medicine and the promise of precision health.

Latest News From Genomes2People

June 2023
Press
Should a baby’s genes be sequenced at birth? Study finds potential life-saving benefits
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June 2023
Press
‘We arguably saved their lives’: Newborn DNA-sequencing reveals elevated cancer risks for parents
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June 2023
Press Release
DNA sequencing in newborns reveals years of actionable findings for infants and families
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Publications

JAMA Network Open | May 2023
Perspectives of rare disease experts on newborn genome sequencing
Journal of Personalized Medicine | November 2022
Workforce considerations when building a precision medicine program

Research

The second phase of the BabySeq Project, funded again by the NIH, is examining the use of whole genome sequencing to screen a diverse cohort of newborns for genetic childhood disease risk. BabySeq follows the pediatricians’ incorporation of genetic information into newborns’ medical care. This time focusing on a cohort that is representative of the general population, BabySeq aims to collect the data needed to examine what the risks and benefits of newborn genome sequencing might be as we imagine implementing it into everyday care.

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The PopSeq project is the first ever study to return genomic results (gRoR) in an all African American population cohort and a primarily European American cohort, including participants enrolled in the Jackson and Framingham Heart studies. The goal of this project is to study important gRoR outcomes and how they compare between participants in these two cohorts. Our gRoR design will serve as a resource for other population cohort studies and biobanks planning to return genomic results to their study participants. This study will also inform future efforts to scale the labor-intensive process of variant classification and will explore penetrance among populations unselected for family history.

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The Personal Genome Sequencing Outcomes (PeopleSeq) Consortium, funded by the NIH, is one of the first large-scale longitudinal studies to examine the experiences, attitudes and outcomes of apparently healthy adults who have elected to obtain exome or genome sequencing. Data collected will provide valuable information on the potential benefits and costs of performing sequencing in healthy individuals, and key insights into the feasibility of using sequencing to create a more personalized and preventative model of medicine.

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Research In Translational Genomics and Health Outcomes
Genomes to People
G2P Program
Brigham and Women’s Hospital
Harvard Medical School
41 Avenue Louis Pasteur, Suite 301
Boston, MA 02115
Tel: (617) 264-5838
genomes2people.org
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