More and more people want to explore their own medical data, and a DTC genetic test is one way to begin to understand some aspects of your future health.
At a new clinic in Boston, genetic counselor Carrie Blout helps healthy patients get their DNA tested for predispositions to more than 2500 diseases. Bloomberg’s Aki Ito goes through the testing herself, trialing a controversial technology at the forefront of modern medicine.
Babies are tested for a number of conditions soon after birth, but varied approaches to screening worldwide highlight how fragmented the medical profession remains over this vital process.
MIT scientists used a novel tool to try to edit out a genetic risk for Alzheimer’s disease, they report in the journal Science. Dr. Robert Green gives his opinion on the new technology.
Dr. Robert Green on learning of your genetic risk to developing Alzheimer’s quotes: “Not everything has a pill or medical-prevention plan, but many information-seeking persons can find all sorts of benefits in better understanding their risk of future disease.”
Its screen for selected variants of some disease-linked genes gives customers an incomplete picture of their risk—do they know?
A decade ago, it seemed inevitable that every newborn would get a complete gene scan. But there are technical challenges and practical concerns.Dr. Robert Green, from Brigham and Women’s Hospital in Boston, voiced one view about doing that: “If sequencing reveals health risks at any point in life, and if that’s good, then it’s better … Continued
Kristine Trudeau agreed to donate a sample of blood to the Partners HealthCare Biobank, a resource for researchers across the Partners hospital network — including the Brigham and Massachusetts General. By analyzing large numbers of blood samples, scientists can learn how genes contribute to disease. Trudeau shares her experiences as being one the many participants … Continued
Robert Green, MD, MPH, of the Division of Genetics, was included in BIS Research and Insight Monk’s Top 25 Voices in Precision Medicine for his work on medical genetics and genomics.
Under the four-year collaboration, experts in genomic medicine from Harvard and Brigham and Women’s will help guide Sanford researchers in using and interpreting data collected through the Sanford Chip, a $49 pharmacogenomic test to identify genetic risk factors for medication use and more accurately prescribe medications.
Nearly 90 percent of participants who carried a BRCA mutation would have been missed by 23andMe’s test, geneticists found. Dr Robert Green comments, “I think people have the right to their own genetic information, but with that right comes a responsibility. If you are going to go around the medical mainstream, read the caveats.”
Dr. Robert Green, Dr. Jason Vassy, and numerous researchers share their thoughts on the Spain-based Patia that is currently offering an assessment that includes a 16-SNP polygenic risk score.
Pediatric oncologist Dr. Lisa Diller, the Lillian Gollay Knafel Fellow at the Radcliffe Institute for Advanced Study, is exploring genetic testing in newborns that could help them escape severe health consequences.
Highlighting the changes that are happening within direct to consumer testing, experts predict that consumer genomics will become “the new normal,” with the companies in this space and healthcare providers working together to find the best path forward.
Researchers analyzed nearly 5,000 genes looking for the risk of diseases and found that almost 10 percent of babies tested were at risk for a condition that could be treated early.
As principal investigator on the BabySeq Project, Dr. Robert Green shares the findings from the project along with discussion on the expectations and benefits of sequencing healthy babies. Green states, “Suddenly the information available in the genome of even an apparently healthy individual is looking more robust, and the prospect of preventive genomics is looking … Continued
“The larger goal of the fund is to change the way people think about medicine,”Francesco Carrozzini, son of Franca Sozzani, states. “To make medicine more proactive and accessible. By doing so, we can help prevent millions of deaths and diseases.”
In the BabySeq Study, a total of 88% of sequenced neonates had carrier status for one or more rare genetic variants known to be associated with recessive diseases.
A trial called BabySeq, in which researchers performed genomic sequencing on 159 newborns, identified children susceptible to diseases that regular screening doesn’t look for.
Newborn DNA testing offers several potential benefits. Mainly, it could expand the number of conditions clinicians can test for before a child starts showing symptoms, giving them and patients a head start in handling the diseases.
Scientists were stunned by the number of babies with unanticipated genetic findings that could lead to disease prevention in the future.
Robert Green, MD, MPH, the projects’ principal investigator suggests “These results are unexpected and exciting, suggesting that if we examine enough well-established, disease-associated genes, we will unearth monogenic risk variants in more than 10 percent of purportedly healthy individuals.”
At-home genetic testing can help you understand your biology. But before delving into your DNA, consider the caveats.
With genomic testing running at a low cost, why aren’t more people running toward the shelves to grab direct-to-consumer testing? Read this Wired post featuring Dr. Robert Green to learn more!
As 2019 looms before us, it is fair to say that significant—and perhaps surprising—advances will be made in the precision medicine and omics arenas.
The Washington Post brings in genetics expert Dr. Robert Green to clarify some of the misconceptions present in results of ancestry genetic testing.
Having genetic information to determine metabolic predispositions can be a powerful tool tool for staying on a nutrition program, says Robert C. Green. “In some cases, people really are motivated by hearing about something from their own DNA. We all know we have to eat better.”
Dr. Robert Green addresses a new epigenetic test that tracks molecular aging claims to show you how to stay biologically young.
Dr. Robert Green shares a concise overview of the results regarding the MedSeq and BabySeq projects presented at the American Society of Human Genetics 2018 conference.
Dr. Robert Green explains why DNA testing kits can’t reveal anyone’s complete ancestral history.
“All of the crimes that are currently unsolved, which have DNA evidence, there’s now a pathway to trying to locate these perpetrators,” says Dr. Robert Green, a medical geneticist at Brigham and Women’s Hospital and a professor at Harvard Medical School.
Dr. Robert Green points to the potential of genomics not only to reunite family members and put criminals behind bars, but also to predict and prevent heritable diseases and develop new drugs.
“Sequencing at birth could provide a template—a book of life, if you will —to predict conditions or decide what medications to use for an entire lifetime,” says Robert Green, a medical geneticist at Brigham and Women’s and professor at Harvard Medical School who is co-leading the study.
Only about 7 percent of families approached to take part in the BabySeq Project of Brigham Women’s Hospital and Boston Children’s Hospital eventually enrolled, with many citing a lack of interest in research, study logistics, and privacy concerns as reasons for declining to participate.
Listen to WBUR’s radio segment on the BabySeq Project and one of its publications.
“According to Green, the Hastings report tries to take a broad view and is well done and well resourced. But he questioned whether recommendations of this type may be premature, considering that the research arms of NSIGHT are still early in the process of collecting, analyzing, and reporting their data.”
VA researcher, Dr. Jason Vassy, hopes genetic test can help in choosing the right drug to reduce high cholesterol.
Veritas Genetics says it has the largest collection of DNA for people who have lived to the age of 110.
Ancestry tests have “blown up family secrets all over the country”, but is it really helping people for the better to know this information? Read about Dr. Robert Green’s opinions on genomic testing revealing unsuspected familial matters.
Veritas Genetics is looking to sequence individuals with extraordinary skills in order to understand the genome that produced these talents. They are also looking to sequence infants and people who have lived to very old ages.