“Would you have your baby’s genes sequenced at birth? A groundbreaking trial that used whole-genome sequencing to predict newborns’ future health, is starting to reveal the impact it has had on the whole family, seven years down the line.”
“Doctors in many places want to sequence and screen babies’ entire genomes at birth. In America there are projects to do just that at Boston Children’s Hospital, Columbia University and Rady Children’s Hospital in San Diego. A pioneering group at Harvard, known as BabySeq, has recently received money to expand its small-scale work to include … Continued
“Whole-genome sequencing may be the fastest way to diagnose rare complex diseases, but should it be incorporated into healthy newborn screening?” “We are missing the opportunity to address an increasing number of treatable conditions,” says G2P Dr. Robert Green.
The MGB Biobank returned actionable genetics results to 256 participants, 76.3 percent of whom were unaware that they carried a variant that put them at increased risk. The New York Times reports on this return of results process, outlining that some participants wanted to learn this information and others did not.
“Genomics England are poised to a launch a pilot project which will see the genomes of newborn babies sequenced on their very first day of life…In the USA, under a pilot project called BabySeq, a team co-led by Robert Green from Brigham and Women’s Hospital found that across 1,500 genes in 127 healthy and 32 … Continued
“Even before their baby is born, parents face some tough questions: Home birth or hospital? Cloth or disposable diapers? Breast, bottle, or both? But advances in genetic sequencing technology mean that parents will soon face yet another choice: whether to sequence their newborn’s DNA for an overview of the baby’s entire genome.”
“Published in the American Journal of Human Genetics on Monday, the study describes takeaways from an effort by BWH’s Genomes2People (G2P) program to disclose actionable genetic results to research participants who volunteered to contribute to the Mass General Brigham Biobank.”
The latest research from the BabySeq project shows that the delivery of genomic information from healthy newborns does not increase anxiety in parents.
This year, Erin Drake, MA, director of operations for G2P, and Tala Berro, MS, CGC, a genetic counselor and project manager, helped launch the G2P BIPOC internship program in recognition of the importance of diversity not only in clinical trials but also in research teams. Research trainees Soha Mohammed, Kopika Kuhathaas and Shardae Williams share … Continued
“Medical researchers in Boston are helping sign up one million volunteers for a first-of-its-kind study [The All of Us Research Program] examining the link between genes and our health. Researchers are actively recruiting volunteers of different races and ethnicities to ensure that the study reflects the diversity of the United States.”
Genomic testing for Baby Cora, a participant of The BabySeq Project, revealed a disorder that might otherwise have gone undetected through traditional newborn screening. “Cora’s case illustrates the promise of sequencing the entire genomes of newborns: uncovering a bounty of genetic information that could identify infants needing treatment and improve health later in life…Genomics England … Continued
“We have now shown that this information can be medically beneficial through early intervention and is not disruptive to the parent-infant relationship, and our ongoing analysis is measuring economic effects of genome sequencing. This type of research is critical to determine best practices for preventive genomic healthcare throughout the lifespan.” – Robert Green
“Researchers examined how conducting genome sequencing on newborns can impact family dynamics.”
“When parents were surveyed about measures like how well they bonded with their children, their levels of distress, and even the parents’ relationships with one another, there were no meaningful differences for parents whose children had their genomes sequenced compared to those whose children underwent standard newborn screening.”
“Researchers studying the psychosocial effect of newborn genomic sequencing on families in the BabySeq project have found that there was no persistent negative psychosocial harm in families who received such sequencing, nor among those who received a monogenic disease risk finding for their infants.”
“Robert Green, MD, MPH, of the Division of Genetics, received a research grant from the National Institutes of Health (NIH) to fund The BabySeq Project: Phase II, also known as BabySeq2, the continuation of a project to study genome sequencing in newborns.”
“Should people who volunteer for genomic studies be told about unrelated disease mutations that turn up in their sequence data?”
ZARA launches its first tribute collection, featuring iconic photographs by legendary image maker Peter Lindbergh. 100% of proceeds from this limited edition series curated by Fabien Baron will be donated to The Franca Sozzani Fund for Preventive Genomics, supporting the Global BabySeq Project in collaboration with Brigham and Women’s Hospital and Harvard Medical School.
Joint project between Ariadne Labs and Genomes2People to create implementation pathways, tools and guides that work across various clinical contexts.
“In 2019, [G2V’s] Morgan Danowski graduated and joined Boston VA. There, she supports VA’s Million Veteran Program (MVP), now the world’s largest genomics research program. The program takes DNA from participating Veterans and information on their health, lifestyle and military experiences and exposures to better understand disease in Veteran populations. With over 830,000 Veterans enrolled, … Continued
Washington University researchers recently published a study in the New England Journal of Medicine reporting that it is often faster and more effective to sequence the genome of people with blood cancers than to order them traditional tests. Dr. Green says that the findings from this study are a start, but despite the tremendous enthusiasm … Continued
In light of the ACMG’s lobbying of state legislatures concerning genetic counselors’ scope of practice, G2P’s director Dr. Green comments on the collaboration between physicians and genetic counselors, describing genetic counselors as “instigators and implementers” of genetic testing.
28 year old Mercey Livingston shares about what it means to be adopted and not know important information related to family health history and genetic health. Livingston quotes G2P’s director, Dr. Robert Green, explaining the differences between direct to consumer testing and comprehensive testing options, as well as the value of working with a genetics … Continued
In this article, Dr. Robert C. Green weighs in on 23andMe’s new interactive tool called the COVID-19 Severity Calculator. Right now the COVID-19 Severity Calculator only includes nongenetic risk factors for hospitalization from COVID-19. Dr. Green suspects that as more insights on genetic risk factors become available, 23andMe might begin incorporating genetic data into their … Continued
“Last year Sozzani’s son, the photographer and filmmaker Francesco Carrozzini, established the Franca Sozzani Fund for Preventive Genomics at Harvard University’s Brigham and Women’s Hospital with artist and investor D.A. Wallach and Genomes2People director Dr. Robert C. Green. Today marks the launch of thefrancafund.org. Its purpose is straightforward: to explain the fund’s mission, provide resources … Continued
“Personal genetic testing is here to stay – so Bethany Zettler and Renée Pelletier recommend preventive genomics clinics as a way to offer the testing patients want without bypassing the guidance they need to fully understand their results.”
Brigham genomics clinic makes medicine personal—and preventive.
“Aging can be considered a disease—one that can be targeted, treated, and perhaps even reversed…The new Preventive Genomics Clinic at Brigham and Women’s Hospital in Boston is the first academic clinic in the country to offer comprehensive DNA sequencing and interpretation of nearly 6,000 disease-associated genes.”
In this study led by UCSF researchers, exome sequencing was found to produce more false positives and false negatives for inherited metabolic disorders than the standard blood testing conducted in newborns. G2P’s Dr. Robert Green, co-leader of the BabySeq Project, speaks to the possibility “that the most comprehensive screening for newborns will be some combination … Continued
In the first of a two-part series, AMA Chief Experience Officer Todd Unger discusses genetics at play in COVID-19 with experts Wendy Chung, MD, PhD, Robert Green, MD, MPH, and AMA’s Chief Health and Science Officer Mira Irons, MD.
Boston researchers using COVID-19 patients’ DNA to unlock secrets about impact of virus
To help scientists around the globe study Covid-19, researchers in Boston have shared genetic and other clinical data from thousands of patients with an international consortium. That data includes information from dozens of people with Covid-19, who had donated blood samples and opened up their medical records before the pandemic.
Dr. Robert Green is the director of the Preventive Genomics Clinic at Brigham and Women’s Hospital in Boston. He believes that DNA testing combined with proper counseling and medical follow-up would be a critical element of a healthcare system that can prevent illness.
Our genes might make some of us more susceptible to COVID-19—but which genes? Geneticists are sharing their vast DNA databases to find out.
“..There are researchers – every single scientist is thinking ‘how can I contribute?’”
“While healthy young people as a group are less likely to have severe symptoms with COVID, they have to understand that some of them will become very ill and will even die from this infection,” Dr. Robert Green said. “No one should assume youth makes them invulnerable.”
An exclusive Clinical OMICs conversation with the director of Genomes2People, Robert Green, M.D., MPH
Through national research efforts like the All of Us Research Program, Brigham investigators and their collaborators are making genomic research more meaningful, equitable and impactful for all patients at the Brigham and around the world.