Highlighting the changes that are happening within direct to consumer testing, experts predict that consumer genomics will become “the new normal,” with the companies in this space and healthcare providers working together to find the best path forward.
Researchers analyzed nearly 5,000 genes looking for the risk of diseases and found that almost 10 percent of babies tested were at risk for a condition that could be treated early.
As principal investigator on the BabySeq Project, Dr. Robert Green shares the findings from the project along with discussion on the expectations and benefits of sequencing healthy babies. Green states, “Suddenly the information available in the genome of even an apparently healthy individual is looking more robust, and the prospect of preventive genomics is looking … Continued
“The larger goal of the fund is to change the way people think about medicine,”Francesco Carrozzini, son of Franca Sozzani, states. “To make medicine more proactive and accessible. By doing so, we can help prevent millions of deaths and diseases.”
In the BabySeq Study, a total of 88% of sequenced neonates had carrier status for one or more rare genetic variants known to be associated with recessive diseases.
A trial called BabySeq, in which researchers performed genomic sequencing on 159 newborns, identified children susceptible to diseases that regular screening doesn’t look for.
Newborn DNA testing offers several potential benefits. Mainly, it could expand the number of conditions clinicians can test for before a child starts showing symptoms, giving them and patients a head start in handling the diseases.
Scientists were stunned by the number of babies with unanticipated genetic findings that could lead to disease prevention in the future.
Robert Green, MD, MPH, the projects’ principal investigator suggests “These results are unexpected and exciting, suggesting that if we examine enough well-established, disease-associated genes, we will unearth monogenic risk variants in more than 10 percent of purportedly healthy individuals.”
At-home genetic testing can help you understand your biology. But before delving into your DNA, consider the caveats.
With genomic testing running at a low cost, why aren’t more people running toward the shelves to grab direct-to-consumer testing? Read this Wired post featuring Dr. Robert Green to learn more!
As 2019 looms before us, it is fair to say that significant—and perhaps surprising—advances will be made in the precision medicine and omics arenas.
The Washington Post brings in genetics expert Dr. Robert Green to clarify some of the misconceptions present in results of ancestry genetic testing.
Having genetic information to determine metabolic predispositions can be a powerful tool tool for staying on a nutrition program, says Robert C. Green. “In some cases, people really are motivated by hearing about something from their own DNA. We all know we have to eat better.”
Dr. Robert Green addresses a new epigenetic test that tracks molecular aging claims to show you how to stay biologically young.
Dr. Robert Green shares a concise overview of the results regarding the MedSeq and BabySeq projects presented at the American Society of Human Genetics 2018 conference.
Dr. Robert Green explains why DNA testing kits can’t reveal anyone’s complete ancestral history.
“All of the crimes that are currently unsolved, which have DNA evidence, there’s now a pathway to trying to locate these perpetrators,” says Dr. Robert Green, a medical geneticist at Brigham and Women’s Hospital and a professor at Harvard Medical School.
Dr. Robert Green points to the potential of genomics not only to reunite family members and put criminals behind bars, but also to predict and prevent heritable diseases and develop new drugs.
“Sequencing at birth could provide a template—a book of life, if you will —to predict conditions or decide what medications to use for an entire lifetime,” says Robert Green, a medical geneticist at Brigham and Women’s and professor at Harvard Medical School who is co-leading the study.
Only about 7 percent of families approached to take part in the BabySeq Project of Brigham Women’s Hospital and Boston Children’s Hospital eventually enrolled, with many citing a lack of interest in research, study logistics, and privacy concerns as reasons for declining to participate.
Listen to WBUR’s radio segment on the BabySeq Project and one of its publications.
“According to Green, the Hastings report tries to take a broad view and is well done and well resourced. But he questioned whether recommendations of this type may be premature, considering that the research arms of NSIGHT are still early in the process of collecting, analyzing, and reporting their data.”
VA researcher, Dr. Jason Vassy, hopes genetic test can help in choosing the right drug to reduce high cholesterol.
Veritas Genetics says it has the largest collection of DNA for people who have lived to the age of 110.
Ancestry tests have “blown up family secrets all over the country”, but is it really helping people for the better to know this information? Read about Dr. Robert Green’s opinions on genomic testing revealing unsuspected familial matters.
Veritas Genetics is looking to sequence individuals with extraordinary skills in order to understand the genome that produced these talents. They are also looking to sequence infants and people who have lived to very old ages.
The third and final interview conducted with Dr. Robert Green about specific circumstances that could arise from genetic sequencing starting from infancy.
“The promises and peril that could come from reading your full genome.” Dr. Robert Green discusses some very important questions about what information you could find in your genome.
Laura Diamond’s 23andMe results noted she had a genetic mutation, BRCA 1, which could increase her risk for breast cancer. When she was screened a few years later, an MRI showed that she had developed stage 1 breast cancer. Direct-to-consumer testing paid off in her case, as she was aware of her condition and was … Continued
Rita Steyn, who has a family history of cancer, decided to order a home genetic testing kit to look for certain genetic mutations that might increase her risk for the disease. While this is something many people are doing, consulting a physician is still recommended in order to understand the real risks, and what the … Continued
For a few hundred dollars and a spit sample, you too could take a journey of genetic self-discovery. You may learn some things, but what are you giving away? Before you spit, it helps to know what you’re getting into.
The bloodTyper algorithm developed with MedSeq data can be used to prevent serious complications and transfusion-related deaths.
Whole genome sequencing (WGS) can help identify rare blood-type donors and transfusion recipients who may be at risk of adverse reactions from red blood cell antigen mismatches.
Mitochondrial DNA is not the only thing we inherit from our mothers; we’re all a mix of traits inherited from both parents.
A study of two groups of 100 patients found no evidence that whole genome sequencing increases downstream healthcare costs. The story begins on Page 12.
Police were able to identify and arrest the Golden State Killer using GEDmatch, an open source genetic database. where individuals can upload and share their information for free, making it accessible for law enforcement in cases like these.
With much controversy still surrounding newborn genetic sequencing, many ask whether this is really the future of medicine. Parents of newborns share some of their experiences with the LA Times.
Dr. Robert C. Green talks about The BabySeq Project, the world’s first study of genetically sequencing newborns, and how genetic information can influence one’s medical care beginning from birth.
Findings in whole-genome sequencing don’t lead to excessive follow-up testing, an early study found.