Return of incidental/unanticipated omics

Understanding the return of genomic sequencing results process: Content review of participant summary letters in the eMERGE research network

Lynch JA, Sharp RR, Aufox SA, Bland ST, Blout CL, Bowen DJ, Buchanan AH, Halverson C, Harr M, Hebbring SJ, Henrikson N, Hoell C, Holm IA, Jarvik G...Smith ME, Sturm A, Stuttgen K, Wiesner G, Williams MS, Wynn J, Williams JL

Journal of Personalized Medicine May 2020

Returning results in the genomic era: Initial experiences of the eMERGE network

Wiesner GL, Rahm AK, Appelbaum P, Aufox S, Bland S, Blout CL, Christensen KD, Chung WK, Clayton EQ, Green RC...Sharp RR, Smith ME, Van Driest SL, Williams JL, Williams MS, Wynn J, Leppig KA

Journal of Personalized Medicine April 2020

The case for implementing sustainable routine, population-level genomic reanalysis

Lu CY, Hendricks-Sturrup RM, Mazor KM, McGuire AL, Green RC, Rehm HL

Genetics in Medicine December 2019

Harmonizing clinical sequencing and interpretation for the eMERGE III network

eMERGE Consortium

American Journal of Human Genetics August 2019

Partners Biobank surpasses 100,000 participants

Brigham Bulletin |

August 2019

Press

“I would have never known that I was at risk if i hadn’t donated to the Biobank,” said Kristine Trudeau who knowingly enrolled in the Partners HealthCare Biobank because she wanted to help advance medicine and potentially save lives. She did not expect that it would save her own.

Blood samples reveal valuable data — and life-changing surprises for donors

The Boston Globe |

July 2019

Press

Kristine Trudeau agreed to donate a sample of blood to the Partners HealthCare Biobank, a resource for researchers across the Partners hospital network — including the Brigham and Massachusetts General. By analyzing large numbers of blood samples, scientists can learn how genes contribute to disease. Trudeau shares her experiences as being one the many participants … Continued

How frequently should genomic results be updated?

Medium |

June 2019

G2P Blog

Continuous new discoveries about the genome make updates important.

Analyzing and reanalyzing the genome: Findings from the MedSeq project

Machini K, Ceyhan-Birsoy O, Azzariti DR, Sharma H, Rossetti P, Mahanta L, Hutchinson L, McLaughlin H, Green RC, Lebo M, Rehm HL

American Journal of Human Genetics June 2019

Sanford Health taps Harvard, Brigham and Women’s for genetic screening study

Genome Web |

June 2019

Press

Under the four-year collaboration, experts in genomic medicine from Harvard and Brigham and Women’s will help guide Sanford researchers in using and interpreting data collected through the Sanford Chip, a $49 pharmacogenomic test to identify genetic risk factors for medication use and more accurately prescribe medications.

Psychological outcomes related to exome and genome sequencing result disclosure: A meta-analysis of seven Clinical Sequencing Exploratory Research (CSER) Consortium studies

Robinson JO, Wynn J, Biesecker B, Biesecker LG, Bernhardt B, Brothers KB, Chung WK, Christensen KD, Green RC …Veenstra D, Cronin AM, Gray SW

Genetics in Medicine June 2019

G2P Newsletter March 2019

March 2019

G2P News

Spring saw accomplishments by team members through numerous projects. G2P officially kicked-off the PeopleSeq consortium in Boston this January! Our very own, Carrie Blout, MS, CGC, was one of 86 Partner’s individuals awarded the Partners In Excellence Award.

Dr. Robert Green on the impact of individual genomic data

Harry Glorikian |

December 2018

Podcast

Harry Glorikian guest this week, Dr. Robert Green, is a professor of medicine and genetics at Harvard Medical School and director of the Genomes To People research program at Brigham & Women’s Hospital and the Broad Institute of Harvard and MIT. They dig into the individual genome, how genomic data is being used, and the impact … Continued

G2P Newsletter December 2018

December 2018

G2P News

This Fall, G2P has had exciting updates with a new PeopleSeq grant. Our team has traveled from San Diego, Atlanta, and Fort Detrick to Basel, Zurich, and Barcelona, to several conferences, presenting new data from our translational genomics research projects.

Reconciling opportunistic and population screening in clinical genomics

Brothers KB, Vassy JL, Green RC

Mayo Clinic Proceedings January 2019

BabySeq, MedSeq projects reveal how many people carry genetic risk variants for rare diseases

Brigham Women's Hospital |

October 2018

Press Release

More information on newborn and adult sequencing studies unveiled at the 2018 American Society for Human Genetics Meeting in San Diego, CA. Two projects in which healthy individuals have had their genomes sequenced have revealed that searching for unanticipated genetic results in newborns and adults can unearth far more variants associated with diseases than previously thought, … Continued

Millions of Americans could be identified using consumer genetic databases—even if they’ve never taken a DNA test

Time |

October 2018

Press

“All of the crimes that are currently unsolved, which have DNA evidence, there’s now a pathway to trying to locate these perpetrators,” says Dr. Robert Green, a medical geneticist at Brigham and Women’s Hospital and a professor at Harvard Medical School.

Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multi-site study

Hart MR, Biesecker BB, Blout CL, Christensen KD, … Veenstra DL, Berg JS, Green RC, Biesecker LG, Hindorff LA

Genetics In Medicine October 2018

Plenary presentation at the Advances in Genome Biology and Technology Precision Health Meeting

AGBT Precision Health Conference |

September 2018

Video

Dr. Robert C. Green speaks at the 2018 Advances in Genome Biology and Technology (AGBT) Precision Health Conference in San Diego, California about our efforts to gather empirical data on genome sequencing healthy individuals. Watch to learn more about G2P’s MilSeq, BabySeq, MedSeq, PeopleSeq, PGen and REVEAL projects. Click here for more on the conference.

Approaches to carrier testing and results disclosure in translational genomics research: The clinical sequencing exploratory research consortium experience

Porter KM, Kauffman TL, Koenig BA, Lewis KL, Rehm HL, Richards CS, Strande NT, Tabor HK, Wolf SM, Yang Y, Amendola LM, Azzariti DR, Berg JS, Bergstrom, Biesecker LG, Biswas S, Bowling KM, Chung WK, Clayton EW, Conlin LK, Cooper GM, Dulik MC, Garraway LA, Ghazani AA, Green RC, Hiatt SM, Jamal SM, Jarvik GP, Goddard KAB, Wilfond BS

Molecular Genetics & Genomic Medicine August 2018

My ancestry test revealed a genetic bombshell

New York Post |

August 2018

Press

Ancestry tests have “blown up family secrets all over the country”, but is it really helping people for the better to know this information? Read about Dr. Robert Green’s opinions on genomic testing revealing unsuspected familial matters.

Challenging the current recommendations for carrier testing in children

VanNoy GE, Genetti CA, McGuire AL, Green RC, Beggs AH, Holm IA

Pediatrics January 2019

Returning a genomic results for an adult-onset condition to the parents of a newborn: Insights from the BabySeq Project

Holm IA, McGuire AL, Pereira S, Rehm HL, Green RC, Beggs AH

Pediatrics January 2019

Privacy and consumer genetic testing don’t always mix

ScienceNews |

June 2018

Press

For a few hundred dollars and a spit sample, you too could take a journey of genetic self-discovery. You may learn some things, but what are you giving away? Before you spit, it helps to know what you’re getting into.

Genome sequencing for healthy people: Will it be harmful?

Medium |

March 2018

G2P Blog

The second piece of a 2-part blog series authored by Dr. Robert C. Green. An early study found no problems related to unnecessary or harmful medical follow-ups after healthy people received their genome sequencing results. To read the first piece, visit: https://medium.com/@genomes2people/genome-sequencing-for-healthy-people-will-it-be-helpful-b984b94e3d3f

Genome sequencing for healthy people: Will it be helpful?

Medium |

February 2018

G2P Blog

The first piece of a 2-part blog series authored by Dr. Robert C. Green. Early results suggest that yes, whole genome sequencing may very well be substantially helpful to a significant number of healthy patients. To read the second piece, visit: https://medium.com/@genomes2people/genome-sequencing-for-healthy-people-will-it-be-harmful-d915cc08e634

Preferences for the return of individual results from research on pediatric biobank sample

Christensen K, Savage SK, Huntington N, Weitzman E, Ziniel S, Bacon P, Cacioppo C, Green RC, Holm IA. Journal of Empirical Research on Human Research Ethics.

Journal of Empirical Research on Human Research Ethics April 2017

You didn’t ask for these genomic test results, but they might save your life

Huffington Post |

April 2017

G2P Blog

We found that almost exactly 1% of the populations in both FHS and JHS carried a pathogenic variant in one of the original ACMG56 genes. And we found that those carrying pathogenic variants had an increased aggregated risk of developing clinical features associated with the corresponding diseases.

Aggregate penetrance of genomic variants for actionable disorders in European and African Americans

Natarajan P, Gold NB, Bick AG, McLaughlin H, Kraft P, Rehm HL, Peloso GM, Wilson JG, Correa A, Seidman JG, Seidman CE, Kathiresan S, Green RC.

Science Translational Medicine November 2016

Genomes2People: a roadmap for genomic medicine

Front Line Genomics |

May 2016

Press

An overview and summary of the main projects that are being conducted within the G2P program, both past and present. This article also includes the progract managers and research assistants on each major project.

An eMERGE clinical center at Partners Personalized Medicine

Smoller JW, Karlson EW, Green RC, Kathiresan S, MacArthur DG, Talkowski ME, Murphy SN, Weiss ST. Journal of Personalized Medicine.

Journal of Personalized Medicine January 2016

Potential psychosocial risks of sequencing newborns

Frankel LA, Pereira S, McGuire AL.

Pediatrics January 2016

Disclosing secondary findings from pediatric sequencing to families: Considering the benefit to families

Wilfond BS, Fernandez CV, Green RC.

The Journal of Law October 2015

The development of a preference setting model for the return of individual genomic research results

Bacon PL, Harris ED, Ziniel SI, Savage SK, Weitzman ER, Green RC, Huntington NL, Holm IA.

Journal of Empirical Research on Human Research Ethics February 2015

Participant satisfaction with a preference-setting tool for the return of individual research results in pediatric genomic research

Holm IA, Iles BR, Ziniel SI, Bacon PL, Savage SK, Christensen KD, Weitzman ER, Green RC, Huntington NL

Journal of Empirical Research on Human Research Ethics January 2015

Reducing false-positive incidental findings with ensemble genotyping and logistic regression based variant filtering methods

Hwang K-B, Lee I-H, Park J-H, Hambuch T, Choe Y, Kim MH, Lee K, Song T, Neu MB, Gupta N, Kohane IS, Green RC, Kong SW.

Human Mutation June 2014

Parents’ preferences for return of results in pediatric genomic research

Ziniel S, Savage SK, Huntington N, Amatruda J, Green RC, Weitzman ER, Taylor P, Holm IA

Public Health Genomics March 2014

Guidelines for return of research results from pediatric genomic studies: Deliberations of the Boston Children’s Hospital Gene Partnership Informed Cohort Oversight Board

Holm IA, Savage SK, Green RC, Juengst E, McGuire A, Kornetsky S, Brewster SJ, Joffe S, Taylor P.

Genetics in Medicine January 2014

Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium

Berg JS, Amendola LM, Eng C, Van Allen E, Gray SW, Wagle N, Rehm HL, DeChene ET, Dulik MC, Hisama FM, Burke W, Spinner NB, Garraway L, Green RC, Plon S, Evans JP, Jarvik GP, and members of the CSER Actionability and Return of Results Working Group.

Genetics in Medicine October 2013