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Revealing the hidden impact of whole-genome sequencing for newborns

New Scientist |
August 2022
Press

“Would you have your baby’s genes sequenced at birth? A groundbreaking trial that used whole-genome sequencing to predict newborns’ future health, is starting to reveal the impact it has had on the whole family, seven years down the line.”

Full-genome screening for newborn babies is now on the cards

The Economist |
May 2022
Press

“Doctors in many places want to sequence and screen babies’ entire genomes at birth. In America there are projects to do just that at Boston Children’s Hospital, Columbia University and Rady Children’s Hospital in San Diego. A pioneering group at Harvard, known as BabySeq, has recently received money to expand its small-scale work to include … Continued

Baby’s first genome

Nature Biotechnology |
April 2022
Press

“Whole-genome sequencing may be the fastest way to diagnose rare complex diseases, but should it be incorporated into healthy newborn screening?” “We are missing the opportunity to address an increasing number of treatable conditions,” says G2P Dr. Robert Green.  

Genomics in Health Implementation Forum newborn sequencing virtual workshop

Genomics in Health Implementation Forum |
April 2022
Video

On April 5th, 2022, initiatives from around the globe will virtually convene for a meeting of the Genomics in Health Implementation Forum (GHIF). This focused workshop aims to share the status of international efforts establishing genomic newborn screening programs and identify areas for engagement with GA4GH Work Streams.

The UK’s plan to sequence the genomes of 200,000 newborn babies

Geographical |
November 2021
Press

“Genomics England are poised to a launch a pilot project which will see the genomes of newborn babies sequenced on their very first day of life…In the USA, under a pilot project called BabySeq, a team co-led by Robert Green from Brigham and Women’s Hospital found that across 1,500 genes in 127 healthy and 32 … Continued

Genomic screening of healthy newborns gets more popular

WebMD |
December 2021
Press

“Even before their baby is born, parents face some tough questions: Home birth or hospital? Cloth or disposable diapers? Breast, bottle, or both? But advances in genetic sequencing technology mean that parents will soon face yet another choice: whether to sequence their newborn’s DNA for an overview of the baby’s entire genome.”

Amy McGuire on newborn sequencing

The Beagle Has Landed |
November 2021
Podcast

“Amy McGuire [Co-PI of BabySeq] joins Laura Hercher on “The Beagle Has Landed” to discuss BabySeq and the high-risk, high-reward prospect of making genome sequencing of newborns routine. After a preliminary study many years in the making, Amy is here to assure us of one thing: ‘what we’re doing isn’t Gattaca.’ Also, the take-home message: … Continued

Sequencing every newborn’s genome to detect diseases faces ethical and practical obstacles, but the United Kingdom is pushing ahead with a major test

Science |
September 2021
Press

Genomic testing for Baby Cora, a participant of The BabySeq Project, revealed a disorder that might otherwise have gone undetected through traditional newborn screening. “Cora’s case illustrates the promise of sequencing the entire genomes of newborns: uncovering a bounty of genetic information that could identify infants needing treatment and improve health later in life…Genomics England … Continued

Study finds genomic sequencing of healthy newborns does not disrupt family dynamics

EurekAlert! |
August 2021
Press, Press Release

“We have now shown that this information can be medically beneficial through early intervention and is not disruptive to the parent-infant relationship, and our ongoing analysis is measuring economic effects of genome sequencing. This type of research is critical to determine best practices for preventive genomic healthcare throughout the lifespan.” – Robert Green

Green receives NIH research grant for BabySeq2

Brigham Publications: Awards, Honors & Grants |
August 2021
Press

“Robert Green, MD, MPH, of the Division of Genetics, received a research grant from the National Institutes of Health (NIH) to fund The BabySeq Project: Phase II, also known as BabySeq2, the continuation of a project to study genome sequencing in newborns.”

Robert Green: Newborn sequencing is the goal here in the U.S.

Mendelspod |
July 2021
Podcast

“If you go to a scientific meeting, even with the greatest critics, and you ask, how many people in this audience believe that your entire genome will be part of your everyday medical care in fifty years, every person will raise their hand. So the only questions we’re debating are: how do we get there, … Continued

Gene-targeted therapies: Early diagnosis and equitable delivery

NIH |
June 2022
Video

This free 3 day NIH sponsored conference brings academia, industry, and government together to accelerate access to gene-targeted therapies. G2P’s Dr. Robert Green co-chairs the planning committee and will be one of the speakers opening the conference on June 3 as well as speaking about BabySeq on June 10.

Newborn sequencing in genomic medicine and public health (NSIGHT)

Advisory Committee on Heritable Disorders in Newborns and Children |
December 2020
Video

Dr. Robert C. Green gives talk at the December 2020 Meeting of the Advisory Committee on Heritable Disorders in Newborns and Children on “Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT).”

Genomic sequencing to screen newborns raises more false alarms than routine blood tests

STAT |
August 2020
Press

In this study led by UCSF researchers, exome sequencing was found to produce more false positives and false negatives for inherited metabolic disorders than the standard blood testing conducted in newborns. G2P’s Dr. Robert Green, co-leader of the BabySeq Project, speaks to the possibility “that the most comprehensive screening for newborns will be some combination … Continued

BabySeq participant "Baby Cora" and her mother

BabySeq: Partial Biotinidase Deficiency

Youtube |
June 2020
Video

Meet BabySeq participants, Cora and her mom. Through our NIH-funded BabySeq Project, Cora was diagnosed with partial biotinidase deficiency, which was missed on her traditional newborn screening test. Listen to their story.

23 and baby

Nature |
December 2019
Press

We now have the ability to screen for thousands of genetic diseases in newborns. That may not always be the healthy thing to do.

The case for preventive genomics: BabySeq

NSIGHT Steering Committee |
June 2019
Video

Dr. Robert C. Green presents on the case for preventive genomics: BabySeq at the 2019 NSIGHT Steering Committee Meeting.

21st Future of Health Technology Summit: Preventive genomics now!

Future of Health Technology Institute |
May 2019
Video

Preventive Genomics Now! Robert Green M.D., MPH, Professor of Medicine (Genetics) Director, Genomes2People Research Program, Brigham and Women’s Hospital, Broad Institute, at 21st Future of Health Technology Summit at MIT Bartos Theatre produced by Renata Bushko Founder Future of Health Technology Institute FHTI since 1995.

DNA testing could save young lives through early intervention

The Harvard Gazette |
March 2019
Press

Pediatric oncologist Dr. Lisa Diller, the Lillian Gollay Knafel Fellow at the Radcliffe Institute for Advanced Study, is exploring genetic testing in newborns that could help them escape severe health consequences.

Is it too soon to consider genome sequencing for newborns?

Medium |
March 2019
G2P Blog

Parents and clinicians have their own ideas about newborn genome sequencing. Dr. Robert Green, principal investigator of the BabySeq Project, shares a detailed analysis of the results from the study and his thoughts on the utility of genomic sequencing for newborns in clinical care.

Genetically sequencing healthy babies yielded surprising results

Leapsmag |
January 2019
Press

As principal investigator on the BabySeq Project, Dr. Robert Green shares the findings from the project along with discussion on the expectations and benefits of sequencing healthy babies. Green states, “Suddenly the information available in the genome of even an apparently healthy individual is looking more robust, and the prospect of preventive genomics is looking … Continued

Inside AJHG: A chat with Alan Beggs

American Society of Human Genetics |
January 2019
Press

In this American Journal of Human Genetics interview, Alan Beggs discusses his recently published paper, Interpretation of Genomic Sequencing Results in Healthy and Ill Newborns: Results from the BabySeq Project.

Baby sequencing steps

Nature Reviews Genetics |
January 2019
Press

In the BabySeq Study, a total of 88% of sequenced neonates had carrier status for one or more rare genetic variants known to be associated with recessive diseases.

Newborn genomic sequencing detects unanticipated disease risk factors

Brigham Women's Hospital |
January 2019
Press Release

Press Brief: The BabySeq project reports that out of the 159 newborns that were randomized to receive genomic sequencing, 15 were found to have a genetic variant for which there was a strong evidence of increased risk of a disorder that presents or is clinically manageable during childhood.