Genomics in military

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho Y, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitebourne S, Cohen J, Posner DC, Sangar R, Murrary M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh S, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP

Science July 2024

Development and utility of a clinical research informatics application for participant recruitment and workflow management for a return of results pilot trial in familial hypercholesterolemia in the Million Veteran Program

Brunette CA, Yi T, Danowski ME, Cardellino M, Harrison A, Assimes TL, Knowles JW, Christensen KD, Sturm AC, Sun YV, Hui Q, Pyarajan S, Shi Y, Whitbourne SB, Gaziano JM, Muralidhar S, Vassy JL

Journal of the American Medical Informatics Association | PMID: 38464744 March 2024

Helping patients understand multi-cancer early detection tests: a scoping review

Greene MP, Vassy J

Precision Medicine January 2024

ThinkResearch Podcast: Genomics and Healthcare

Harvard Catalyst |

January 2024

Podcast

“What role can genomics play in improving healthcare? Jason Vassy, MD, MPH, MS, of Veterans Affairs (VA) Boston Healthcare System and Brigham and Women’s Hospital shares his research on how patient DNA might be used to improve healthcare and prevent disease.”

G2P December Newsletter 2023

G2P News |

December 2023

G2P News

G2P’s final newsletter of 2023 celebrates the five year anniversary of The Franca Sozzani Fund for Preventive Genomics. Other highlights include the second annual meeting of the International Consortium on Newborn Sequencing (ICoNS) in London and the 2023 Advisory Board members of the year, Mike and Ann Marie Einziger. We also join Genomes2Veterans in celebrating … Continued

V.A. Recruits Millionth Veteran for Its Genetic Research Database

New York Times |

November 2023

Press

“On Saturday, after a 12-year effort, the Department of Veterans Affairs reached a long-term goal — it enrolled the millionth veteran in a genetic database, the Million Veteran Program. According to the V.A., the Million Veteran Program is the largest such database in the world. It includes not only genetic information but also is linked … Continued

The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care

Vassy JL, Brunette CA, Lebo MS, MacIsaac K, Yi T, Danowski ME, Alexander NVJ, Cardellino MP, Christensen KD, Gala M, Green RC, Harris E, Jones NE, Kerman BJ, Kraft P, Kulkarni P, Lewis ACF, Lubitz SA, Natarajan P, Antwi AA

The American Journal of Human Genetics November 2023

Cardiovascular disease risk assessment using traditional risk factors and polygenic risk scores in the Million Veteran Program

Vassy JL, Posner DC, Ho YL, Gagnon DR, Galloway A, Tanukonda V, Houghton SC, Madduri RK, McMahon BH, Tsao PS, Damrauer SM, O’Donnell CJ, Assimes TL, Casas JP, Gaziano JM,Pencina MJ, Sun YV, Cho K, Wilson PWF

JAMA Cardiology May 2023

Physicians and patient holding roadmap with DNA helix

Navigating the uncertainty of precision cancer screening: The role of shared decision-making

Gallagher JH, Vassy JL, Clayman ML

Patient Education and Counseling Innovation | PMID: 37214512 January 2023

Airmen and healthcare providers’ attitudes toward the use of genomic sequencing in the US Air Force: Findings from the MilSeq Project

Pereira S, Hsu RL, Islam R, Robinson JO, Ramapriyan R, Sirotich E, Maxwell MD, Majumder M, Blout C, Christensen KD, Mehlman M, Parasidis E, Gardner CL, Killian JM, De Castro M, Green RC, McGuire AL

Genetics in Medicine August 2020

Educating military primary health-care providers in genomic medicine: lessons learned from the MilSeq Project

Maxwell MD, Hsu R, Islam R, Robinson JO, Pereira S, Gardner CL, Green RC, De Castro M

Genetics in Medicine July 2020

The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study: Protocol for a point-of-care randomized controlled trial of statin pharmacogenetics in primary care

Vassy JL, Brunette CA, Majahalme N, Advani S, MacMullen L, Hau C, Zimolzak AJ, Miller SJ

Contemporary Clinical Trials October 2018

BabySeq, MedSeq projects reveal how many people carry genetic risk variants for rare diseases

Brigham Women's Hospital |

October 2018

Press Release

More information on newborn and adult sequencing studies unveiled at the 2018 American Society for Human Genetics Meeting in San Diego, CA. Two projects in which healthy individuals have had their genomes sequenced have revealed that searching for unanticipated genetic results in newborns and adults can unearth far more variants associated with diseases than previously thought, … Continued

Plenary presentation at the Advances in Genome Biology and Technology Precision Health Meeting

AGBT Precision Health Conference |

September 2018

Video

Dr. Robert C. Green speaks at the 2018 Advances in Genome Biology and Technology (AGBT) Precision Health Conference in San Diego, California about our efforts to gather empirical data on genome sequencing healthy individuals. Watch to learn more about G2P’s MilSeq, BabySeq, MedSeq, PeopleSeq, PGen and REVEAL projects. Click here for more on the conference.

Pharmacogenetic testing in the Veterans Health Administration (VHA): Policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee

Vassy JL, Stone A, Callaghan, JT, Mendes M, Meyer LJ, Pratt VM, Przygodzki RM, Scheuner MT, Wang-Rodriguez J, Schichman SA

Genetics In Medicine June 2018

G2P Newsletter April 2018

Genomes2People |

April 2018

G2P News

Spring saw accomplishments by team members and new advances in direct-to-consumer testing. Dr. Kurt Christensen provides compelling detail about econogenomics cost and benefits to genetic sequencing, and Megan Maxwell discusses genetic counseling and the MilSeq project on a podcast.

G2P Newsletter October 2017

Genomes2People |

October 2017

G2P News

Highlights include a CBS feature on the BabySeq Project, the announcement of the MilSeq collaboration with the U.S. Air Force, and more.

Air Force sequencing study to inform broader genomic medicine implementation among service members

GenomeWeb |

October 2017

Press

The US Air Force is studying the future of personalized medicine through MilSeq, a joint venture with several academic organizations, including Genomes2People.

Study of clinical genome sequencing in the active-duty military begins

Brigham Women's Hospital |

October 2017

Press Release

Up to 75 active-duty U.S. Air Force service members will now have the first opportunity to incorporate whole exome sequencing (WES) into their routine clinical care through a new two-year research partnership between the Air Force Personalized Medicine Program, Air Force Medical Genetics Center and several academic institutions, including Brigham Women’s Hospital, Broad Institute, Harvard … Continued

Genomes2People: a roadmap for genomic medicine

Front Line Genomics |

May 2016

Press

An overview and summary of the main projects that are being conducted within the G2P program, both past and present. This article also includes the progract managers and research assistants on each major project.

Genomic medicine in the military

De Castro M, Biesecker LG, Turner C, Brenner R, Witkop C, Mehlman M, Bradburne C, Green RC

Genomic Medicine January 2016

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