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Study finds genomic sequencing of healthy newborns does not disrupt family dynamics

EurekAlert |
August 2021
Press, Press Release

“We have now shown that this information can be medically beneficial through early intervention and is not disruptive to the parent-infant relationship, and our ongoing analysis is measuring economic effects of genome sequencing. This type of research is critical to determine best practices for preventive genomic healthcare throughout the lifespan.” – Robert Green

Green receives NIH research grant for BabySeq2

Brigham Publications: Awards, Honors & Grants |
August 2021
Press

“Robert Green, MD, MPH, of the Division of Genetics, received a research grant from the National Institutes of Health (NIH) to fund The BabySeq Project: Phase II, also known as BabySeq2, the continuation of a project to study genome sequencing in newborns.”

Robert Green: Newborn sequencing is the goal here in the U.S.

Mendelspod |
July 2021
Podcast

“If you go to a scientific meeting, even with the greatest critics, and you ask, how many people in this audience believe that your entire genome will be part of your everyday medical care in fifty years, every person will raise their hand. So the only questions we’re debating are: how do we get there, … Continued

Genomic sequencing to screen newborns raises more false alarms than routine blood tests

STAT |
August 2020
Press

In this study led by UCSF researchers, exome sequencing was found to produce more false positives and false negatives for inherited metabolic disorders than the standard blood testing conducted in newborns. G2P’s Dr. Robert Green, co-leader of the BabySeq Project, speaks to the possibility “that the most comprehensive screening for newborns will be some combination … Continued

23 and baby

Nature |
December 2019
Press

We now have the ability to screen for thousands of genetic diseases in newborns. That may not always be the healthy thing to do.

DNA testing could save young lives through early intervention

The Harvard Gazette |
March 2019
Press

Pediatric oncologist Dr. Lisa Diller, the Lillian Gollay Knafel Fellow at the Radcliffe Institute for Advanced Study, is exploring genetic testing in newborns that could help them escape severe health consequences.

Is it too soon to consider genome sequencing for newborns?

Medium |
March 2019
G2P Blog

Parents and clinicians have their own ideas about newborn genome sequencing. Dr. Robert Green, principal investigator of the BabySeq Project, shares a detailed analysis of the results from the study and his thoughts on the utility of genomic sequencing for newborns in clinical care.

Genetically sequencing healthy babies yielded surprising results

Leapsmag |
January 2019
Press

As principal investigator on the BabySeq Project, Dr. Robert Green shares the findings from the project along with discussion on the expectations and benefits of sequencing healthy babies. Green states, “Suddenly the information available in the genome of even an apparently healthy individual is looking more robust, and the prospect of preventive genomics is looking … Continued

Baby sequencing steps

Nature Reviews Genetics |
January 2019
Press

In the BabySeq Study, a total of 88% of sequenced neonates had carrier status for one or more rare genetic variants known to be associated with recessive diseases.

Newborn genomic sequencing detects unanticipated disease risk factors

Brigham Women's Hospital |
January 2019
Press Release

Press Brief: The BabySeq project reports that out of the 159 newborns that were randomized to receive genomic sequencing, 15 were found to have a genetic variant for which there was a strong evidence of increased risk of a disorder that presents or is clinically manageable during childhood.

More than 10% of healthy people have monogenic risk variants

RareDR |
December 2018
Press

Robert Green, MD, MPH, the projects’ principal investigator suggests “These results are unexpected and exciting, suggesting that if we examine enough well-established, disease-associated genes, we will unearth monogenic risk variants in more than 10 percent of purportedly healthy individuals.”

BabySeq, MedSeq projects reveal how many people carry genetic risk variants for rare diseases

Brigham Women's Hospital |
October 2018
Press Release

More information on newborn and adult sequencing studies unveiled at the 2018 American Society for Human Genetics Meeting in San Diego, CA. Two projects in which healthy individuals have had their genomes sequenced have revealed that searching for unanticipated genetic results in newborns and adults can unearth far more variants associated with diseases than previously thought, … Continued

The new, improved world of infant care

Wall Street Journal |
September 2018
Press

“Sequencing at birth could provide a template—a book of life, if you will —to predict conditions or decide what medications to use for an entire lifetime,” says Robert Green, a medical geneticist at Brigham and Women’s and professor at Harvard Medical School who is co-leading the study.

Genomic sequencing for newborns: Are parents receptive?

Boston Children's Hospital |
September 2018
G2P Blog

Casie Genetti, MS, CGC, a licensed genetic counselor with the Manton Center for Orphan Disease Research at Boston Children’s Hospital is first author of a recently published paper on the BabySeq Project and author of this blog about parents’ receptiveness to genome sequencing.

HBO’s VICE News reports on the BabySeq Project

HBO VICE News |
May 2018
Video

Follow new parents Katherine and Jason as they meet with Genomes2People Genetic Counselors to learn about their baby boy’s genome sequencing results as part of our BabySeq Project.

Would you have your newborn genetically tested?

The Doctors |
March 2018
Press, Video

Dr. Robert C. Green talks about The BabySeq Project, the world’s first study of genetically sequencing newborns, and how genetic information can influence one’s medical care beginning from birth.

Pick the right controversy- Robert Green

Front Line Genomics |
July 2017
Press

Everyone talks about generating the clinical utility data necessary to integrate genomics into healthcare, but no one has taken this to heart more, or generated more of it, than Dr. Robert Green.

Baby genome sequencing for sale in China

MIT Technology Review |
June 2017
Press

“The idea of finding a risk in their beautiful baby of something that might or might not happen is terrifying or repugnant,” he says. “But other types of people are information seekers.”

Research rumble: A communication battle of the science stars

Brigham Clinical and Research News |
May 2017
Press

The project has two aims: One is to evaluate the risks and benefits of genome sequencing in healthy and sick infants, with the goal of developing evidence to support guidelines for use of this technology in newborn screening or care. The second objective is to study parents’ thoughts and feelings about genetic testing, as well … Continued

Full genome sequencing for newborns raises questions

Scientific American |
March 2017
Press

“We are moving to a world where the technology will get so good and the cost will get so low that it will be very appealing to apply sequencing to not only sick people but well people,” says geneticist Robert C. Green.

Are you ready to explore your baby’s genome?

Brigham Women's Hospital |
January 2017
Press Release

“Simply putting together all the pieces to design these complicated research projects is an ambitious undertaking. But it is essential that we find ways to rigorously measure the clinical utility of new technologies so that we can apply them responsibly, and that is the focus of the BabySeq Project, and of the other NSIGHT projects.”

Three parent babies’ may be headed here

Boston Herald |
December 2016
Press

In-vitro fertilization, above, that uses DNA from two mothers to prevent some serious diseases has been approved in Britain, and Dr. Robert Green, a geneticist at Brigham and Women’s Hospital, says the U.S. will be pressed to follow suit.