This Nature article highlights how nationwide genetic screening shows promise for early disease risk detection. Evidence from a large Australian pilot demonstrates population-wide genetic screening in young adults can successfully identify individuals at increased risk for serious heritable conditions, including hereditary cancers and high cholesterol, before symptoms arise. The findings outline the potential of early genetic testing to improve preventive care and tailor health interventions, while also underscoring the need for further studies to understand cost-effectiveness and broader applicability in diverse health systems.

